Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Kunkle, B.W., Grenier-Boley, B., Sims, R. et al. Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat Genet 51, 414–430 (2019). https://doi.org/10.1038/s41588-019-0358-2
Subspecific origin and haplotype diversity in the laboratory mouse
Yang, H., Wang, J., Didion, J. et al. Subspecific origin and haplotype diversity in the laboratory mouse. Nat Genet 43, 648–655 (2011). https://doi.org/10.1038/ng.847
Genome assemblies of 11 bamboo species highlight diversification induced by dynamic subgenome dominance
Ma, PF., Liu, YL., Guo, C. et al. Genome assemblies of 11 bamboo species highlight diversification induced by dynamic subgenome dominance. Nat Genet (2024). https://doi.org/10.1038/s41588-024-01683-0
Epigenetic variation impacts individual differences in the transcriptional response to influenza infection
Aracena, K.A., Lin, YL., Luo, K. et al. Epigenetic variation impacts individual differences in the transcriptional response to influenza infection. Nat Genet 56, 408–419 (2024). https://doi.org/10.1038/s41588-024-01668-z
Tumor mutational load predicts survival after immunotherapy across multiple cancer types
Samstein, R.M., Lee, CH., Shoushtari, A.N. et al. Tumor mutational load predicts survival after immunotherapy across multiple cancer types. Nat Genet 51, 202–206 (2019). https://doi.org/10.1038/s41588-018-0312-8
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Demontis, D., Walters, R.K., Martin, J. et al. Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nat Genet 51, 63–75 (2019). https://doi.org/10.1038/s41588-018-0269-7
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
Verbanck, M., Chen, CY., Neale, B. et al. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet 50, 693–698 (2018). https://doi.org/10.1038/s41588-018-0099-7
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Wray, N.R., Ripke, S., Mattheisen, M. et al. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet 50, 668–681 (2018). https://doi.org/10.1038/s41588-018-0090-3